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The history of the red vine leaf
 
Almost all wine produced today throughout the world can be traced back to vines originating in the Transcaucasus (the present Georgia and Armenia). The earliest finding providing evidence for the cultivation of the vine comes from ancient Mesopotamia (the present Iraq and Syria) and has been dated back to the 4th millennium BC. Amphora decorated with vine motifs, estimated to date from 3500 BC, have also been found in Iran. Viticulture came to Europe via Egypt, Greece and Spain. 

Medical science has been benefiting from this vine (Vitis vinifera L. Vitaceae) since Antiquity. This applies particularly to the vine leaf (Folia Vitis viniferae), which Galen, a physician at the court of the Roman caesar, Marcus Aurelius (2nd Century AD), made medicinal use of. In medieval literature, alongside Christian medical teaching, a medical indication is also to be found for instance in "Liber floridus", written by Canon Lambert of St. Omer's in Flanders around 1120. Albert the Great (1198 - 1280), whose knowledge of the natural sciences was exceptional for those times, described the medicinal effects of the vine leaf in great detail. 

The traditional practice of using vine leaves has been maintained. In many European countries, the leaves of the vine have long been used in folk medicine and for therapeutic purposes. Infusions and paste-like poultices were prepared from vine leaves and tendrils which were successfully used to treat skin disorders, bleeding, rheumatic complaints, but above all venous insufficiency of the lower limbs. Red vine leaf extract has thus been used in France for decades for the treatment of vein disorders and has an entry in the national pharmacopoeia as "Vigne rouge" for this indication. 

ANTISTAX®, which principal mechanism of action is based on red vine leaf extract, has been on the market in Germany, Austria and Switzerland for some years now. It is suitable for systemic and topical use in vein disorders.

 
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